Detection of Clindamycin-Resistant Staphylococcus aureus Isolated from clinical specimens in Baghdad

Abstract

Background: Staphylococcus aureus represent one of the opportunistic pathogens that related to acute and chronic infections. Clindamycin consider as drug of choice for many S. aureus resistance strains. Although, many of these strains develop resistance to clindamycin which resulted in a treatment failure. Objective: This study aimed to determine the clindamycin resistant pattern among multi-drug resistant S. aureus isolates. Martials and Methods: 150 samples were collected from clinical sources in Baghdad. All samples were subjected to analyses and confirmed by VITEK2 system. As a result, 80 isolates were recognized as S. aureus. Disc diffusion method was used to test antibiotic susceptibility profile for the isolates towards 8 antibiotics. Results: The results indicated that 12 isolates were multi-drug resistant (MDR), 11 isolates were extensively drug-resistant (XDR) and 8 were pandrug-resistant (PDR). Twenty-eight (35%) of the isolates were clindamycin resistant and 21 (26%) of these were constitutive clindamycin resistance as they show resistance towards erythromycin too; while 52 (65%) of the isolates were sensitive to both clindamycin and erythromycin and 7 isolates were reported to be erythromycin-sensitive but clindamycin-resistant. Conclusion: It is essential that all healthcare facilities should continuously monitor S. aureus for avoid treatment failures associated with induced lincosamid antibiotics resistance.